A water-dispersible extract of shikuwasa (Citrus depressa) from Okinawa, standardized to min. 10% polymethoxyflavones, measured as the sum of nobiletin and tangeretin. The flavones are held in a cyclic oligosaccharide, which makes them easier to dissolve in water. The producer's recommended intake is 10-45 mg of powder per day.
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Shikuwasa grown in Okinawa is first pressed for juice. The peel that remains is extracted with hydrous ethanol, and the extract is combined with a cyclic oligosaccharide as it is made into powder. The specification sets polymethoxyflavones at min. 10%, measured as nobiletin plus tangeretin.
Step 1 · Okinawa
Citrus depressa Hayata, 100% Okinawan raw material
Step 2 · by-product
The peel left after juicing is the starting material
Step 3 · hydrous ethanol
Polymethoxyflavones extracted from the juicing residue
Step 4 · cyclic oligosaccharide
Flavones held in cyclodextrin as the powder is made
Step 5 · PMF min. 10%
Loss on drying, heavy metals, arsenic, microbiology
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Example lot values are published in the developer's guide below. They are an example, not a specification; your lot's CoA governs.
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After payment is received. Freight quoted on request. Specification and SDS before you order, CoA with the goods.
If you are comparing ingredients for a new SKU, these questions separate one material from another quickly.
Here polymethoxyflavones are the sum of nobiletin and tangeretin on an anhydrous basis, min. 10%. Other offers may state nobiletin alone or total flavonoids, so compare the definition, not only the number.
The powder contains a cyclic oligosaccharide (cyclodextrin). The producer's labelling example is "shikuwasa extract / cyclic oligosaccharide"; check how your market lists it.
The producer's recommended intake is 10-45 mg of powder per day. In a capsule or tablet this is a small share of each unit, so plan the blend for even distribution.
Some markets permit only listed botanicals or treat new extracts as novel foods. Check the status for your category before launch; registration of the finished product sits with the brand owner or importer.
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What each component is, what the processing changes, and what published research on the raw material has examined. No health claims; references on request.
Shikuwasa Extract Powder is a standardized source of nobiletin and tangeretin, two polymethoxyflavones found mainly in citrus peel. The specification sets them at min. 10% of the powder, and the producer's recommended intake is 10-45 mg of powder per day, or 1.0-4.5 mg of polymethoxyflavones.
Because the dose is small, a little powder goes a long way: at 10-45 mg per day, 100 g covers about 2,200 to 10,000 daily intakes, and 1 kg about 22,000 to 100,000.
The producer documents use in supplements, health foods, drinks and jellies. The cyclodextrin inclusion lets the powder dissolve in water at the recommended intake, which opens up drinks and jellies, and it reduces the bitterness typical of shikuwasa. In capsules and tablets the powder makes up a small part of each unit.
Need finished capsules rather than powder? We also make OEM supplements in Japan: see OEM supplements. Other Japanese polyphenol ingredients: Ashitaba Chalcone Powder 8% and Red Pine Needle Extract (Concentrate).
To discuss price, volume or your application, or to request the specification or a sample, use the request form on this page.
Shikuwasa (also spelled shiikuwasha or shikwasa, and known as hirami lemon) is Citrus depressa Hayata, a small citrus native to southern Japan and Taiwan. A study of 23 strains from Okinawa, Kagoshima and Taiwan found that their polymethoxyflavone levels, nobiletin and tangeretin among them, differ from strain to strain (Journal of Oleo Science, 2026).
Polymethoxyflavones (PMFs) are flavonoids in which several hydroxyl groups are replaced by methoxy groups. The plant builds them by O-methylation of flavonoids, and Citrus depressa is known to accumulate nobiletin in the peel of its fruit (BMC Plant Biology, 2016). Nobiletin carries six methoxy groups and tangeretin five; both are fat-soluble.
Citrus species differ in which PMFs they contain and in how much: a comparison of seven species detected 38 PMFs in total and found higher yields in wild-type species than in common commercial ones (Planta Medica, 2021). Shikuwasa peel, usually discarded after juicing, has been studied as a source of nobiletin and tangeretin; in that work, 50% ethanol extracted more flavonoids than water (Current Research in Food Science, 2022). This powder also starts from the peel left after juicing and uses hydrous ethanol.
Nobiletin dissolves very poorly in water, below 1 µg/mL, which is why formulation work on it focuses on improving solubility (AAPS PharmSciTech, 2020). Cyclodextrins are ring-shaped oligosaccharides made from starch; a poorly water-soluble molecule can sit inside the ring, which helps it disperse in water. In this powder, nobiletin and tangeretin are held in such a cyclic oligosaccharide.
Nobiletin has been widely studied. Laboratory and animal research has examined, among other topics, its interaction with the cellular circadian clock (review: Biochemistry (Moscow), 2020). This research was not conducted on this product and is not a claim for it; the statements a finished product may carry are set by the rules of its market.
Start at the minimum order. Free sample. Specification, SDS and lot CoA on request.
Request a sample or quotationShikuwasa Extract Powder is a standardized source of nobiletin and tangeretin, two polymethoxyflavones found mainly in citrus peel. The specification sets them at min. 10% of the powder, and the producer's recommended intake is 10-45 mg of powder per day, or 1.0-4.5 mg of polymethoxyflavones.
Because the dose is small, a little powder goes a long way: at 10-45 mg per day, 100 g covers about 2,200 to 10,000 daily intakes, and 1 kg about 22,000 to 100,000.
The producer documents use in supplements, health foods, drinks and jellies. The cyclodextrin inclusion lets the powder dissolve in water at the recommended intake, which opens up drinks and jellies, and it reduces the bitterness typical of shikuwasa. In capsules and tablets the powder makes up a small part of each unit.
Need finished capsules rather than powder? We also make OEM supplements in Japan: see OEM supplements. Other Japanese polyphenol ingredients: Ashitaba Chalcone Powder 8% and Red Pine Needle Extract (Concentrate).
To discuss price, volume or your application, or to request the specification or a sample, use the request form on this page.
Shikuwasa (also spelled shiikuwasha or shikwasa, and known as hirami lemon) is Citrus depressa Hayata, a small citrus native to southern Japan and Taiwan. A study of 23 strains from Okinawa, Kagoshima and Taiwan found that their polymethoxyflavone levels, nobiletin and tangeretin among them, differ from strain to strain (Journal of Oleo Science, 2026).
Polymethoxyflavones (PMFs) are flavonoids in which several hydroxyl groups are replaced by methoxy groups. The plant builds them by O-methylation of flavonoids, and Citrus depressa is known to accumulate nobiletin in the peel of its fruit (BMC Plant Biology, 2016). Nobiletin carries six methoxy groups and tangeretin five; both are fat-soluble.
Citrus species differ in which PMFs they contain and in how much: a comparison of seven species detected 38 PMFs in total and found higher yields in wild-type species than in common commercial ones (Planta Medica, 2021). Shikuwasa peel, usually discarded after juicing, has been studied as a source of nobiletin and tangeretin; in that work, 50% ethanol extracted more flavonoids than water (Current Research in Food Science, 2022). This powder also starts from the peel left after juicing and uses hydrous ethanol.
Nobiletin dissolves very poorly in water, below 1 µg/mL, which is why formulation work on it focuses on improving solubility (AAPS PharmSciTech, 2020). Cyclodextrins are ring-shaped oligosaccharides made from starch; a poorly water-soluble molecule can sit inside the ring, which helps it disperse in water. In this powder, nobiletin and tangeretin are held in such a cyclic oligosaccharide.
Nobiletin has been widely studied. Laboratory and animal research has examined, among other topics, its interaction with the cellular circadian clock (review: Biochemistry (Moscow), 2020). This research was not conducted on this product and is not a claim for it; the statements a finished product may carry are set by the rules of its market.
It is a hydrous ethanol extract of shikuwasa (Citrus depressa Hayata) fruit, made from the peel that remains after juicing, combined with a cyclic oligosaccharide. The specification sets polymethoxyflavones at min. 10%, measured as the sum of nobiletin and tangeretin on an anhydrous basis. The raw material is 100% Okinawan shikuwasa, and the producer's labelling example is "shikuwasa extract / cyclic oligosaccharide".
The minimum order is 1 kg at 4,800 USD/kg; larger orders are quoted by volume, and freight is quoted on request. The powder is packed in 100 g or 1 kg bags. Payment is 100% prepayment by SWIFT or Stripe, and orders ship from Japan 1-1.5 weeks after payment. Registered companies developing a product can request a free 5 g sample.
The specification sets polymethoxyflavones at min. 10% (nobiletin plus tangeretin, anhydrous basis), loss on drying at max. 8.0%, arsenic at max. 2 ppm, heavy metals at max. 20 ppm, total viable count at max. 1,000 CFU/g, fungal count at max. 300 CFU/g and coliforms negative. The powder is pale yellow to brown with a characteristic flavour and is stored sealed at room temperature. The specification is available before you order; the lot CoA and SDS are available on request.
The producer's recommended intake is 10-45 mg of powder per day, which equals 1.0-4.5 mg of polymethoxyflavones. Documented uses are supplements, health foods, drinks and jellies. With the cyclodextrin inclusion, the powder dissolves in water at the recommended intake, and the inclusion also reduces the bitterness of shikuwasa.
