A hot-water extract of fenugreek seed, fennel seed and hibiscus calyx, dried to a powder with dextrin and supplied from Japan. The three herbs were selected in glycation research, and the blend has been tested in human studies at 100 and 300 mg per day. For tablets, capsules, drinks, jellies and powder foods.
Tell us what you are developing and which documents you need. We reply from Japan within one working day with the product specification, SDS and the CoA of the current lot.
The material is a hot-water extract of three herbs, dried to a powder that contains dextrin. Herbs that cleave AGE-type crosslinks in glycation assays were selected first; combinations of them were then tested for their effect on the activity of the enzyme OPH, and fenugreek, fennel and hibiscus were chosen. Extraction ratio and the share of dextrin are not part of the product specification.
Step 1 · 3 herbs
Fenugreek seed, fennel seed, hibiscus calyx and bract, chosen in glycation screening
Step 2 · pesticide residues
Residue panels on the raw herbs: 301 items for fenugreek and fennel, 225 for hibiscus
Step 3 · hot water
Extract of the three herbs
Step 4 · with dextrin
Dried extract powder; the product contains dextrin
Step 5 · 6 parameters
Loss on drying, arsenic, heavy metals, total plate count, fungi, coliforms
Step 6 · 1 kg
Aluminium bag, stored sealed at room temperature
The grade on this page. Other grades, where available, are specified on request.
Example lot values are published in the developer's guide below. They are an example, not a specification; your lot's CoA governs.
A Japanese trading company selling directly to brand owners and contract manufacturers. No distributor layer between you and the documents.
Every shipment travels with the Certificate of Analysis of its own lot, with the measured values and the full safety panel.
A small first order lets you run a pilot batch before committing to bulk. Larger volumes are quoted by volume and delivery terms.
For registered companies developing a product. Tell us the format you plan and we will say honestly what to expect.
After payment is received. Freight quoted on request. Specification and SDS before you order, CoA with the goods.
If you are comparing ingredients for a new SKU, these questions separate one material from another quickly.
The human studies on this blend measured AGE markers and skin parameters. Whether a finished product may carry any statement about them depends on the destination market: authorised health claims in the EU, structure/function rules in the US, registered wording elsewhere. We supply study summaries; the wording is the brand owner's decision.
The reference intake is 100 to 300 mg per day, and the human studies used 100 mg and 300 mg per day. At this level the powder fits one tablet or capsule next to other actives.
Fenugreek is a legume, and allergic reactions to it, including cross-reactivity with peanut, have been reported. The documents we hold carry no allergen statement, so plan the allergen review for your market.
The three herbs are used as spices and in herbal tea, but a concentrated extract can be assessed differently. The status check for your market sits with the brand owner or importer; we supply the documents it needs.
The powder has a characteristic extract odour. Test tablets of the blend have been made both sugar-coated and uncoated. Try the sample in your format before you fix the recipe.
Not on file. Halal documentation is often requested for supplements in the UAE and other Muslim-majority markets; ask us and we will check what can be issued for your order.
What each component is, what the processing changes, and what published research on the raw material has examined. No health claims; references on request.
Glycation is a slow reaction between sugars and the body's proteins, and its end products, AGEs, build up on long-lived proteins such as skin collagen over the years (see the guide below). This powder comes out of that research field. Food raw materials were screened in glycation assays, and three herbs with a long history in food were chosen: fenugreek seed, fennel seed and the calyx of edible hibiscus. The extract has been tested in human studies at 100 and 300 mg per day.
The low daily amount leaves room in a tablet or capsule for other actives, which suits beauty-from-within and daily wellness formulas. The powder is used in tablets, hard and soft capsules, drinks, jellies and powder products. In a beauty line it can sit next to a protein base such as Fish Collagen Tripeptide or Fish Elastin Peptide.
The powder is grayish-brown to brown with a characteristic extract odour and contains dextrin. Test tablets of the blend have been made both sugar-coated and uncoated. The specification has no marker compound or assay value: it defines the material by its composition, appearance, loss on drying and the contaminant and microbiology limits.
The minimum order is one 1 kg aluminium bag. Samples are free for registered companies developing a product. The specification, SDS and the Certificate of Analysis for your lot are confirmed with your quotation. Our own OEM line at Tomioka Plant makes finished capsules, tablets and stick packs from 5,000 units per SKU; we check the powder's fit for your format with the sample.
We will help you choose the form and packaging for your brand.
Glycation is the non-enzymatic reaction between reducing sugars, such as glucose, and proteins [1]. The first adduct is reversible, but over time it rearranges into advanced glycation end products (AGEs), which stay bound to the protein and can link neighbouring protein chains together [2]. AGEs formed on long-lived connective tissue such as collagen account for much of the increase in collagen crosslinking that comes with normal ageing [2]. Carboxymethyl-lysine (CML) is the most prevalent AGE in the body, and pentosidine is a fluorescent AGE that forms protein-protein crosslinks [1].
Several AGEs fluoresce, which makes the skin a convenient place to study glycation without a biopsy [1]. A skin autofluorescence reader measures this fluorescence on the arm; in its validation study the readings correlated with pentosidine, CML and CEL measured in skin biopsies from the same site [3]. Glycation-associated skin autofluorescence has also been shown to rise with chronological age in healthy people [1].
Because AGE crosslinks may form through reactive alpha-dicarbonyl intermediates, researchers looked for compounds that cleave them. In 1996, N-phenacylthiazolium bromide (PTB) was described as a prototype AGE crosslink breaker that cleaves AGE-derived protein crosslinks in vitro and in vivo [2]. PTB served as the positive control in the crosslink-cleavage assays on this extract.
Oxidised protein hydrolase (OPH) is a serine protease isolated from human red blood cells and identified as acylpeptide hydrolase. It preferentially breaks down oxidatively damaged proteins, and the recombinant enzyme also degraded glycated albumin in the laboratory. Its peptidase activity can be measured with the substrate N-acetyl-L-alanine p-nitroanilide [4], the same substrate used in the assays on this blend. OPH has been found in human cell lines, in rat brain, heart, liver and kidney, and in human and rat plasma [5].
Fenugreek (Trigonella foenum-graecum) is a leguminous crop whose seeds are prized in cooking; they contain galactomannans, flavonoids, coumarins, saponins, alkaloids and essential oil [6]. Fennel (Foeniculum vulgare) seed is a familiar spice, with volatile compounds, flavonoids and phenolic compounds among its constituents [7]. Roselle (Hibiscus sabdariffa) is used as a food, in hot and cold herbal drinks and as a flavouring; its constituents include the anthocyanins delphinidin-3-sambubioside and cyanidin-3-sambubioside and the organic acids hydroxycitric acid and hibiscus acid [8].
The technical documentation describes the following work. These data are provided for evaluation; they are not claims for a finished product.
Full descriptions, including the reported results, are available to registered companies on request.
Allergic reactions to fenugreek, including cross-reactivity with peanut, have been reported [9], and fenugreek is listed among the non-priority legumes that are potentially important new allergen sources [10]. The documents we hold carry no allergen statement, so plan the allergen review for your market. Statements about the effect of a finished product are the brand owner's responsibility under the rules of the destination market.
Sources
Product facts: product leaflet and technical documentation. Summaries are provided to registered companies on request.
Start at the minimum order. Free sample. Specification, SDS and lot CoA on request.
Request a sample or quotationGlycation is a slow reaction between sugars and the body's proteins, and its end products, AGEs, build up on long-lived proteins such as skin collagen over the years (see the guide below). This powder comes out of that research field. Food raw materials were screened in glycation assays, and three herbs with a long history in food were chosen: fenugreek seed, fennel seed and the calyx of edible hibiscus. The extract has been tested in human studies at 100 and 300 mg per day.
The low daily amount leaves room in a tablet or capsule for other actives, which suits beauty-from-within and daily wellness formulas. The powder is used in tablets, hard and soft capsules, drinks, jellies and powder products. In a beauty line it can sit next to a protein base such as Fish Collagen Tripeptide or Fish Elastin Peptide.
The powder is grayish-brown to brown with a characteristic extract odour and contains dextrin. Test tablets of the blend have been made both sugar-coated and uncoated. The specification has no marker compound or assay value: it defines the material by its composition, appearance, loss on drying and the contaminant and microbiology limits.
The minimum order is one 1 kg aluminium bag. Samples are free for registered companies developing a product. The specification, SDS and the Certificate of Analysis for your lot are confirmed with your quotation. Our own OEM line at Tomioka Plant makes finished capsules, tablets and stick packs from 5,000 units per SKU; we check the powder's fit for your format with the sample.
We will help you choose the form and packaging for your brand.
Glycation is the non-enzymatic reaction between reducing sugars, such as glucose, and proteins [1]. The first adduct is reversible, but over time it rearranges into advanced glycation end products (AGEs), which stay bound to the protein and can link neighbouring protein chains together [2]. AGEs formed on long-lived connective tissue such as collagen account for much of the increase in collagen crosslinking that comes with normal ageing [2]. Carboxymethyl-lysine (CML) is the most prevalent AGE in the body, and pentosidine is a fluorescent AGE that forms protein-protein crosslinks [1].
Several AGEs fluoresce, which makes the skin a convenient place to study glycation without a biopsy [1]. A skin autofluorescence reader measures this fluorescence on the arm; in its validation study the readings correlated with pentosidine, CML and CEL measured in skin biopsies from the same site [3]. Glycation-associated skin autofluorescence has also been shown to rise with chronological age in healthy people [1].
Because AGE crosslinks may form through reactive alpha-dicarbonyl intermediates, researchers looked for compounds that cleave them. In 1996, N-phenacylthiazolium bromide (PTB) was described as a prototype AGE crosslink breaker that cleaves AGE-derived protein crosslinks in vitro and in vivo [2]. PTB served as the positive control in the crosslink-cleavage assays on this extract.
Oxidised protein hydrolase (OPH) is a serine protease isolated from human red blood cells and identified as acylpeptide hydrolase. It preferentially breaks down oxidatively damaged proteins, and the recombinant enzyme also degraded glycated albumin in the laboratory. Its peptidase activity can be measured with the substrate N-acetyl-L-alanine p-nitroanilide [4], the same substrate used in the assays on this blend. OPH has been found in human cell lines, in rat brain, heart, liver and kidney, and in human and rat plasma [5].
Fenugreek (Trigonella foenum-graecum) is a leguminous crop whose seeds are prized in cooking; they contain galactomannans, flavonoids, coumarins, saponins, alkaloids and essential oil [6]. Fennel (Foeniculum vulgare) seed is a familiar spice, with volatile compounds, flavonoids and phenolic compounds among its constituents [7]. Roselle (Hibiscus sabdariffa) is used as a food, in hot and cold herbal drinks and as a flavouring; its constituents include the anthocyanins delphinidin-3-sambubioside and cyanidin-3-sambubioside and the organic acids hydroxycitric acid and hibiscus acid [8].
The technical documentation describes the following work. These data are provided for evaluation; they are not claims for a finished product.
Full descriptions, including the reported results, are available to registered companies on request.
Allergic reactions to fenugreek, including cross-reactivity with peanut, have been reported [9], and fenugreek is listed among the non-priority legumes that are potentially important new allergen sources [10]. The documents we hold carry no allergen statement, so plan the allergen review for your market. Statements about the effect of a finished product are the brand owner's responsibility under the rules of the destination market.
Sources
Product facts: product leaflet and technical documentation. Summaries are provided to registered companies on request.
It is a hot-water extract of three culinary herbs, dried to a powder that contains dextrin: fenugreek (Trigonella foenum-graecum) seed, fennel (Foeniculum vulgare) seed and the calyx and bract of edible hibiscus (Hibiscus sabdariffa, roselle). The combination was selected in laboratory glycation research. It is a grayish-brown to brown powder for tablets, capsules, drinks, jellies and powder foods, supplied from Japan.
The blend has been tested in the laboratory and in people. Laboratory work measured the activity of OPH, an enzyme that breaks down oxidised and glycated proteins, and the cleavage of AGE-type crosslinks in a model compound and in glycated lysozyme. A randomised, double-blind, placebo-controlled study gave 100 mg per day for 12 weeks to healthy adults (19 on the extract, 16 on placebo) and measured skin AGE autofluorescence, blood pentosidine and CML, and facial skin parameters by image analysis; an exploratory open study used 300 mg per day for 12 weeks. Study summaries are available to registered companies on request; they are not claims for a finished product.
Iizuka Shoukai supplies the powder with a 1 kg minimum order, packed in a 1 kg aluminium bag; the price is confirmed in your quotation. Larger orders are quoted by volume and freight is quoted on request. Goods ship from Japan 1-1.5 weeks after payment when stock is available; otherwise timing is confirmed in your quotation. Payment is 100% prepayment by SWIFT or Stripe. Iizuka Shoukai also offers OEM finished-product manufacturing in capsules, tablets and sticks at our Tomioka Plant in Gunma, from 5,000 units per SKU.
The reference intake is 100 to 300 mg per day, and the human studies used 100 mg and 300 mg per day, so the powder fits one tablet or capsule next to other actives. It is used in tablets, hard and soft capsules, drinks, jellies, powder products and general foods. The powder has a characteristic extract odour; test tablets of the blend have been made both sugar-coated and uncoated. An example declaration on Japanese labels is mixed herb extract (dextrin, fenugreek, fennel, hibiscus).
