Akoya Pearl Powder is sourced from genuine Japanese Akoya pearls (Pinctada fucata oyster) harvested in Japan. The manufacturing process involves carefully separating the pearl from its shell nucleus and thoroughly cleaning the nacre (mother-of-pearl) layer to ensure purity. The pearls are then pulverized and ultra-fine milled (micronized) into a soft, high grade powder. This process is done without any calcination (no high-heat treatment), which helps preserve the pearls’ natural nutrients. The final product is 100% pure Akoya pearl powder with no carriers or additives – it is not mixed with any excipients, ensuring the ingredient’s integrity.
Capsules/Tablets. Most commonly, it is encapsulated in beauty supplement capsules. For example, a capsule might contain 20–50 mg of pearl powder along with other skin supporting nutrients. Many Japanese and Chinese beauty supplement brands include pearl powder in their formulations for skin brightening and anti-aging.
Powder Blends. It can be included in nutritional powders or drink mixes (e.g., a collagen drink mix or a superfood blend). Given its insolubility, it works best in mixes that can be shaken or stirred well. Some contemporary wellness brands have started adding pearl powder to protein shakes and “beauty latte” powders for its mineral content and mystique as a traditional beauty ingredient.
Functional Foods. Less commonly, pearl powder can be added to foods (there are examples in Asia of pearl powder chocolates or cookies marketed for beauty). It can also be used in chewable tablets or lozenges.
Conchiolin is a fibrous, insoluble structural protein that forms the organic basis of mollusk shells. It is secreted by the mollusk’s mantle and acts as a natural “cement,” binding together calcium carbonate crystals (aragonite) to build the shell’s hard structure. In nacre (mother-of-pearl), conchiolin layers make up only about 4–6% by weight, yet they play a crucial role: they separate and hold together aragonite crystal layers, which causes the beautiful iridescent luster of pearls. Chemically, conchiolin is a scleroprotein (an albuminoid) rich in amino acids like glycine, arginine, valine, and lysine. It is notably tough and resistant to water and mild acids, similar in character to keratin or collagen, providing durability and resilience to shells.
Humans have valued the effects of conchiolin-containing substances (like pearls) for centuries, especially in traditional medicine. Pearl powder (which naturally contains conchiolin and minerals) has been used in Chinese medicine for over a thousand years for both beauty and health – treating skin ailments, strengthening bones, and calming the mind. Ancient texts and practices describe pearl or shell preparations used for improving complexion and treating ailments such as palpitations, insomnia, and epilepsy. Scientifically, the organic matrix of shells was first recognized in the 19th century, and the term “conchiolin” (from conch- meaning shell) was coined around 1865–1870 to describe this shell protein. Early researchers discovered that even after dissolving the mineral portion of a shell, a resilient organic framework remained – this was conchiolin, which provided insight into how shells are formed and why they are so strong.
Conchiolin is an insoluble, collagen-like protein that gives shells both strength and flexibility. In the shell-forming process, mollusks deposit alternating layers of conchiolin and calcium carbonate; the conchiolin layers impart toughness and prevent brittleness by holding mineral layers together. This unique layered structure (organic protein alternating with mineral) results in a composite material that is remarkably strong and somewhat resistant to acids and heat. Conchiolin itself is comparable to other structural proteins (scleroproteins) in animals: it’s analogous to keratin (found in skin and hair) in that it contributes to hardness and protective function. Notably, conchiolin is responsible for a pearl’s inner glow – the thin conchiolin films between crystal layers create optical interference, giving pearls their iridescence. Biologically, the proteins in conchiolin also guide mineralization: they influence the formation of aragonite crystals (size, shape, orientation), essentially directing how the shell grows. Modern uses leverage these properties: when hydrolyzed (broken into smaller peptides), conchiolin becomes water-soluble and is used in supplements and cosmetics for its moisturizing and regenerative effects. It contains 17 types of amino acids and when ingested or applied, these amino acids can support skin and hair structure similar to dietary collagen.
In a typical diet, conchiolin itself is not commonly encountered – one would have to actually consume parts of shells or pearls to intake this protein. Therefore, the main sources are specialized supplements and traditional remedies:
INTAKE TIMING
Conchiolin-containing supplements are generally advised to be taken by mouth along with meals. Taking pearl or nacre powder with food (or a source of vitamin D) can enhance calcium absorption and reduce any stomach discomfort. For example, a common regimen for nacre capsules (for osteoporosis prevention) is one capsule daily with a meal, over a prolonged period. Since some people use pearl powder for its calming effects, it can be taken in the evening to help with relaxation and sleep, though traditional usage also allows it in the morning for daytime health support. Consistency is key: benefits (especially for bones or skin) accrue over weeks or months.
Conchiolin (as found in pearl or shell powders) has a range of biological effects when taken as a supplement. These effects are a combination of the protein’s direct action and the accompanying minerals and amino acids that come with it. Key reported benefits include:
Conchiolin is often called “pearl protein” for its skinbeautifying properties. It has been shown to promote healthy collagen production in the skin, which helps maintain firmness and reduce wrinkles. In fact, conchiolin’s amino acid profile is similar to that of keratin, a protein essential for skin and hair. By providing building blocks like glycine and proline, it can improve skin hydration, boost cell metabolism, and repair damaged cells. The result is often reported as increased skin suppleness and fewer fine lines. Users of pearl supplements often notice a “pearly” glow to their complexion – indeed, conchiolin was the component that gave pearls their luminescence, and in the skin it can support a radiant, smoother appearance.
Another remarkable effect is skin brightening. Conchiolin has an ability to inhibit melanin synthesis, thereby fading dark spots and promoting a more even skin tone . Scientific studies support this depigmenting action: a 2023 in vitro study found that hydrolyzed conchiolin protein from pearls significantly suppresses tyrosinase activity (the enzyme responsible for melanin production) and downregulates key melanogenesis genes, resulting in lower melanin content in skin cells . This means conchiolin can help lighten hyperpigmentation and age spots. In traditional beauty remedies, pearl powder was used to lighten and brighten the complexion – modern science confirms that conchiolin in pearl can indeed act as a gentle skin whitener by modulating pigment production. Over time, supplementation may lead to a visibly more even, luminous skin tone .
Pearl-based supplements have notable antioxidant effects. They have been found to boost levels of the body’s key antioxidant enzymes, including superoxide dismutase (SOD) and glutathione, which protect cells from oxidative damage . By raising SOD and glutathione activity, conchiolin helps defend against free radicals and may slow down cellular aging and inflammation. This antioxidant property also contributes to preventing the formation of excess melanin (which can cause freckles and discoloration) . In animal studies, pearl powder showed anti-aging effects partly through stimulation of fibroblast activity (cells that produce collagen) . It also exhibited anti-inflammatory and immunomodulatory actions, likely due to its magnesium and amino acid content . Overall, conchiolin’s presence in pearl powder makes it a rejuvenating supplement – protecting DNA from oxidative stress , supporting detoxification, and helping the body maintain youthful function.
Conchiolin-containing nacre has a significant impact on bone health. The combination of the organic matrix with calcium and trace minerals in mother-of-pearl can stimulate bone formation. Research in osteoporotic animal models found that diets supplemented with nacre powder (which includes conchiolin proteins) prevented bone loss far more effectively than calcium alone . The nacre-supplemented group maintained higher bone density and lower bone resorption, indicating a protective, strengthening effect on bone tissue . Scientists attribute this to bioactive conchiolin peptides and proteins in nacre that signal bone-building cells (osteoblasts) to function better . In practical terms, supplements derived from pearl or shell can help increase bone mineral density, promote new bone growth, and improve the quality of bone matrix. They are used to support conditions like osteoporosis, fracture healing, and even dental health (the same nacre components can strengthen dentin and periodontal structures) . For example, clinical feedback on mother-of-pearl capsules has shown benefits in osteoporosis management, periodontal (gum) health, and osteoarthritis symptoms . Thus, conchiolin is a key part of why “pearl calcium” is considered more than just calcium – it’s a holistic bone booster.
Conchiolin promotes regeneration of soft tissues as well. Experiments have demonstrated that pearl extracts can speed up wound healing by enhancing fibroblast migration and activity. In one study, a pearl extract tripled the movement of human fibroblast cells and increased their production of collagen, which is crucial for wound closure and skin repair . The presence of conchiolin and other pearl proteins is believed to stimulate fibroblasts to produce collagen fibers (with an observed increase in collagen type III, which is important in early wound healing) . This leads to faster regeneration of skin and perhaps other connective tissues. Traditional medicine has long used mother-of-pearl for its “tissue growing” properties – for instance, finely ground shell was applied to wounds or taken for peptic ulcers to help heal the mucosal lining . Modern findings support that conchiolin peptides can aid tissue regeneration, making them beneficial for healing skin injuries, and possibly for improving skin elasticity and reducing scar formation.
A well-documented traditional use of pearl (and thus conchiolin) is its sedative and calming effect on the nervous system. Historical texts describe powdered pearl as a remedy for palpitations, anxiety, and insomnia . Modern analysis suggests this is partly due to magnesium in pearl and the influence of conchiolin on neurotransmitters. 37 338 Pearl powder supplementation has been shown to elevate levels of GABA in the brain – GABA is an inhibitory neurotransmitter that produces a relaxing, anti-anxiety effect . By supporting GABA and even serotonin pathways, pearl (with conchiolin and magnesium) can help alleviate stress, ease nervous tension, and promote better sleep quality . Users often report improved sleep and a sense of calm when taking such supplements. Thus, conchiolin’s effect extends to mood support: it is used to “calm the shen” (spirit) in Chinese medicine terms, correlating to reduced anxiety and a more stable mood. This makes conchiolin-containing supplements attractive for people dealing with stress, restlessness, or mild insomnia as a natural calming agent.
Interestingly, while calming, conchiolin doesn’t sedate in a negative way – it can simultaneously support overall vitality. Because pearl/nacre provides a spectrum of amino acids and trace minerals, it has an anti-fatigue and tonic effect on the body . In supplements given to athletes or the elderly, mother-of-pearl has been noted to improve energy levels and aid in post-exercise recovery . The bioavailable minerals (like calcium, magnesium, potassium) and protein components help reduce muscle fatigue and support muscle and nerve function. For older adults or those who are overworked, pearl supplements are said to help maintain energy and reduce exhaustion . This dual action – calming the mind while sustaining physical energy – reflects why it’s considered an adaptogenic substance in some wellness circles. It can help the body adapt to stress and recover, without overstimulation.
Conchiolin’s amino acids (such as aspartic and glutamic acid) also have roles in immune function. Animal studies indicate that pearl powder can modulate immune responses and exhibit mild immunostimulatory effects . Antioxidant amino acids in conchiolin may enhance the immune system by protecting immune cells from oxidative stress . Additionally, traditional use of conchiolin-containing powders for ulcers suggests a benefit to gastrointestinal health. In TCM, pearl powder has been used internally to help heal gastric and duodenal ulcers and mouth sores . The soothing, restorative effect on mucous membranes could be due to the protein matrix forming a protective coating and promoting tissue repair (much like it does in wounds). While more human research is needed, these supplements are sometimes recommended as a complementary approach for those with minor ulcerations or inflammatory conditions of the gut, in addition to standard medical care.
Each of the above effects is supported by historical use or scientific studies, as cited. It’s important to note that many conchiolin benefits have been observed in cell or animal studies; human clinical data is still emerging. Individuals may experience varying results.
Conchiolin Supplements Are Recommended For:
1] Pearl Powder—An Emerging Material for Biomedical Applications: A Review - PMC.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8197316/
2] Pearl extract enhances the migratory ability of fibroblasts in a wound healing model.
https://pubmed.ncbi.nlm.nih.gov/23043617/
3] Hydrolyzed Conchiolin Protein (HCP) Extracted from Pearls Antagonizes both ET-1 and α-MSH for Skin Whitening.
https://pubmed.ncbi.nlm.nih.gov/37108635/
4] Protective Effect on Bone of Nacre Supplementation in Ovariectomized Rats.
https://pubmed.ncbi.nlm.nih.gov/36111203/
The recommended daily intake is 20 mg. This amount is sufficient to deliver the functional benefits of calcium and conchiolin. It can be taken alone or blended into beauty formulas, capsules, or drinks.
Yes, absolutely. Pearl powder pairs well with ingredients like collagen, placenta extract, and elastin peptides. Together, they enhance skin elasticity, hydration, and inner glow — ideal for advanced anti-aging or nutricosmetic formulas.
Every pregnancy is unique, and nutritional needs may vary. While Akoya pearl powder is a natural source of calcium and amino acids, we recommend consulting a healthcare provider before using any supplement during pregnancy.
Japanese Akoya pearl powder contains significantly more conchiolin — the bioactive protein responsible for skin glow, regeneration, and cellular repair. As shown in microscopic imaging, Akoya pearls have a higher density of conchiolin layers, giving them superior bioactivity and mineral structure. This makes Japanese pearl powder a premium choice for beauty and wellness applications.
